Scientific and Toxicity Study of Pueraria mirifica

A series of studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract (Smith Naturals Co Ltd., Bangkok) has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH).

Pueraria mirifica promotes fibroblasts in normal breast cells and inhibits estrogen-dependent breast cancer cells. Unpublished, 2001, Sawatsri, S., Juntayanee, B., Jitpatima, S., Boonnao, P., Kampoo, C., Ayuttaya, N., Wongyai, S. and Sidell, N.

According to the study conducted at the School of Medicine, Saint Mariane University, Tokyo, Japan by Kuramoshi, T. and Smitasiri, Y. about the preliminary study of Pueraria mirifica in Japanese females, 50 healthy menstruating volunteer females, ages 20 to 49, were given between 100 to 600 mg orally of Pueraria mirifica root powder daily as capsules for 7 days, two weeks after menstruation. No reports of abnormally heavy, severe, or missed menstruation were recorded.

Research and Study on Pueraria mirifica

It has been revealed recently that Pueraria mirifica is safe to be used in human in certain dosage as well as consumption period. The researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years. The result shows that the selected Pueraria mirifica contains very high isoflavone content and shows high anti-mutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays, nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection normally found on post-menopausal and people who have hormone imbalance.

The Benefits of Miroestrol and Its Derivatives in Pueraria mirifica

Miroestrol and its derivatives are also precious chemicals in the white kwao kreu which promote estrogenic and mammogenic effects to various tissues such as breast enlargement or breast tissue reformation.

The Differences between Soya and Pueraria mirifica

Soya, the western health food products, contains lower amount of phytoestrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.

Applications of Pueraria mirifica

Pueraria extract is a natural specialty product designed to help promote normal healthy sexual function and rejuvenescence in women. Pueraria mirifica imitates the human estrogen that is a natural body compound affecting the human body, including growth and maintenance of all female sex characteristics. Therefore, when Pueraria mirifica is applied it will help replace the lost estrogen and rejuvenate the specific area.

Local women and rural communities in Thailand have used Pueraria mirifica effectively as a traditional medicine for over hundred of years. Today, extracts from the root of Pueraria mirifica are claimed by mainstream medical researchers, medical physicians and herbalists as a "Fountain of Youth" that manifest properties contributory to rejuvenescence - firms breasts, re-grows hair / strengthens and darkens existing ones, helps improve complexion and reverses wrinkle effects, alleviates cataract problems, increases energy and vigor leading to more reflexive bodily movements, etc.

Although phytoestrogen can also be found in other natural products such as soybeans and bean curt, phytoestrogen in Pueraria mirifica is far greater than that in other products. Apart from daidzin, genistin, and daidzein that are usually found in soybeans, Pueraria mirifica also contains miroestrol which is believed to have 3,000 times of potency more than soybeans in promoting estrogenic activities.

Pueraria mirifica and Women

Most women are very concerned about aging, particularly the effects brought about by the aging process. At a certain age, the body experiences dramatic changes: the body's systems and its functions begin to decelerate and the immune system weakens. For the average woman, menstruation cycles end at 48-50 years of age when the reproductive system stop or slow down functioning. Moreover, it is a fact that women whom no longer menstruate are further troubled by the adverse effects of lower levels of estrogen in the body. Estrogen helps to control the production of free radicals (free radicals are perceived as being harmful for the body because it accelerates degeneration of bodily organs), and therefore lack of estrogen will induce production of free radicals. Consequently, menopausal women will experience both psychological and physiological changes. Psychological changes range from anxiety, tension and nervousness to chronic depression. Whereas the physiological affects include hot flushes, fatigue and insomnia to more severe conditions as bone loss, balding and degeneration of the reproductive area. Pueraria mirifica contains substances that can effectively cope with these problems.

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